DIY Cancer treatment....baking soda or apple cider vinegar
Killing Cancer by changing body PH from acidic back to neutral or basic with sodium bicarbinate
or baking soda....old wive's tale confirmed by scientists at Cancer Center.
Tumor cells engineer acidity to drive cell invasion, Moffitt Cancer Center
Using buffers to increase pH may inhibit cancer growth
Researchers at Moffitt Cancer Center and colleagues at Wayne State University School of Medicine investigated the acidity in solid tumors to determine if pH levels play a role in cancer cell
invasion in surrounding tissues. They found that an acidic microenvironment can
drive cancer cells to spread and propose that neutralizing pH would inhibit
further invasion, providing a therapeutic opportunity to slow the progression
Their study appeared in the Jan. 3 online release of Cancer Research, a publication of the
American Association for Cancer Research.
According to the study's corresponding author, Robert J. Gillies, Ph.D., chair of the Department of
Cancer Imaging & Metabolism at Moffitt, acidity in solid tumors is theresult of an increased fermentative metabolism combined with poor delivery of blood to tissues.
In this study, tumor invasion and pH were monitored in immunodeficient laboratory mice hosting a
variety of tumors. "We monitored the test animals over time using
microscopy and found that the highest regions of tumor invasion corresponded to
areas with the lowest pH," Gillies explained. "Tumor invasion did not
occur in regions with normal or near normal pH levels. Furthermore, when we neutralized the acidity with oral sodium bicarbonate, the invasion was halted."
Researchers proposedthat the acidic pH of the tumor microenvironment represents a "niche
engineering" strategy on the part of tumor cells, promoting invasion and
growth of malignant tumors into surrounding tissue. Niche engineering is a
concept in ecology describes how plants and animals alter their environment to
in ways that promote their own growth and survival over their competitors.
"We have long regarded cancers cells as an invading species," said study co-author Robert Gatenby, M.D., chair of the Diagnostic Imaging Services and Integrated Mathematical Oncology departments at
A key to this process of adaptation and invasion is increased glucose metabolism in
the tumor. "The vast majority of malignant tumors metabolize glucose at
high rates," Gillies said. "We have proposed that there is a direct,
causative link between increased glucose metabolism and the ability of cancer
cells to invade and metastasize."
According to the research, elevated glucose metabolism is the cause of increased acidity in the
tumor microenvironment. Most tumors develop an abnormal vascular network that
tends to be poorly organized and leaky, disrupting blood flow and hampering the
delivery of oxygen.
"This poorly organized vascular system has a two-fold effect on tumor acidity,"
explained Gatenby. "First, it subjects tumor regions to poor perfusion,
which restricts oxygen and increases the rate of glucose fermentation. Second,
the poor perfusion hampers the ability to eliminate the resulting acids,
resulting in very low pH in surrounding tissues."
As tumor cells adapt to increasing acidity, niche engineering through normal cell death and new blood
vessel formation occurs in the tumor and the immune response is suppressed.
"Tumor cells perform niche engineering by creating an acidic environment that is not toxic to
the malignant cells but, through its negative effects on normal cells and
tissues, promotes local invasion of malignant cells," Gatenby said.
The researchers suggested that targeting this activity with buffers and other mechanisms aimed
at increasing pH levels will likely provide a valuable alternative to
traditional therapies focused entirely on killing tumor cells.
Funding for this study came from federal grants U54 CA143970; R01 CA 077575; R01 CA 131990S.
About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions
to clinical trials, prevention and cancer control. Since 1999, Moffitt has been
listed in U.S. News & World Report as one of "America's Best Hospitals" for
cancer. With more than 4,200 employees, Moffitt has an economic impact on the
state of nearly $2 billion. For more information, visit MOFFITT.org, and follow
the Moffitt momentum on Facebook, twitter and YouTube.
Media release by Florida
Public release date: 25-Jan-2013
Contact: Kim Polacek
H. Lee Moffitt Cancer Center &