Cure for & preventive treatment against Alzheimer's disease on the Horizon using Hydrated Fullerenes

A team of scientists from Kharkiv, Ukraine, who have been working with water-soluble fullerenes (or hydrated fullerenes that they discovered & patented) since 1993, have announced the initial results of their work in finding a cure for the debilitating disease of Alzheimer's. Many people, sceptics and other scientists will downplay or outrightly dismiss this discovery because it wasn't invented in the West or in Japan with their multi-million dollar research budgets, but IMHO, this is still world class research and a new disruptive technology category. (....need more information on hydrated fullerenes? contact us; serious inquiries only)

See Effects of Hydrated Forms of C60 Fullerene on Amyloid ß-Peptide Fibrillization In Vitro and Performance of the Cognitive Task  from Journal of Nanoscience and Nanotechnology, Volume 7, Numbers 4-5, April/May 2007 , pp. 1479-1485(7)

Abstract:

"It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C60 inhibited the fibrillization of amyloid-ß25-35 peptide.  The fullerene affected the amyloid-ß25-35 assembly, manifesting its anti-amyloidogenic capacity.  Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats.  The intracerebroventricular injection of the C60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-ß25-35 (22.5 nmol/ventricle).  The results obtained may be useful in the development of therapy of Alzheimer's disease."

Many more years of clinical trials are needed before we see this drug on the market

ETA: 2017 or sooner if it comes out as a new health drink catagory for prevention

N.B This group, lead by Dr G.V. Andrievsky, is in the stage of scaling up from a limited laboratory benchtop production capability to planning a startup to manufacture hydrated fullerenes (HyFn’s) for medical and nonmedical applications.

Several exciting potential market applications exist for HyFn’s (as published in peer-reviewed academic journals since 1993) --either as

• a reagent grade solution for experimental lab work sold to other scientists & labs around the world,
• a totally new niche/market of health drinks (as a preventive anti-oxidant, health drink )
• as a health supplement
• for pre-clinical and clinical trials for patients with: 1) cancer metastasis, 2) alcohol addiction, 3) Alzheimer’s, 4) viral and 5) bacterial infections such as HIV, Avian Flu, 6) atherosclerosis activity (blood clots), 7) diabetes, 8) asthma etc any disease that has an inflammatory component in its pathway (and a whole new "extreme" medical tourism market once it gets approval)
• contrast agents for diagnostic imaging
• radio-protective agents in cancer therapy
• topical cosmetics (already on the market in Japan)
• drug delivery /carrier agent for other drugs
• pharmaceuticals
• nutraceuticals and programmable foods
• Long term (fullerenes in the water supply like we do this flourides today?)

or for non-medical uses, (which could be brought to market faster) such as

• thin films,
• OLEDs,
• solar cells
• fullerene based semiconductors,
• lubricants,
• superconductors.
• super caps
• environmental cleanup

It appears that hydrated fullerenes (HyFn) not only have a curative effect but a preventive effect as well (think new anti-oxidant water drink category with hydrated fullerenes or fullerenes added to the water supply, the way we add chlorine or fluoride to toothpaste today)

HyFn challenge the prevailing notion in medicine, that you need a specific drug which acts on a specific receptor to cure a specific disease. HyFn’s appear to act across a broad universal spectrum of diseases.

The following table was reproduced with the permission of the authors:

Basic biological properties of aqueous solution of the hydrated C60 fullerene

(HyFn) detected to the present time (May 2005)

In vitro experiments revealed that HyFn with C60 concentrations up to 100mM/l:

1. Are non-toxic for cells including hepatocytes;

2. Do not suppress, but promote the growth of isolated micro-organisms (microbes, fungi, etc.) and improve the survival rate and viability of cells

(e.g., frozen-thawed spermatozoa);

3. Do not inhibit cell respiration;

4. Do not suppress membrane-bonded ATP-ase activity;

5. Possess more significant anti-oxidant properties then vitamin E, b-carotene and BHT (2,6-di-tert-butyl-4-kresol);

6. Stabilize cellular membranes and enhance their resistance to adverse conditions;

7. Do not affect blood coagulation;

8. Increase by 5–10 degree C the temperature of biomolecule denaturation (DNA), albumin, collagen and etc.);

9. Increase catalytic activity of isolated enzymes (e.g., serine proteases).

In vivo experiments revealed that HyFn with C60 total doses up to 25mg/kg of b.w.:

1. Are non-toxic, not immunogenic, not allergenic;

2. Increase resistance of plasma membranes to damaging factors;

3. Positive influence on anti-oxidant and energetic systems of organisms;

4. Possess radioprotective properties due to suppression of excess level of free radicals;

5. Possess antihistaminic and allergy-suppressing abilities, i.e., act as anti-inflammatory agents,

6. Positive influence on activity of adrenergic, GABA-, hystaminic- and, especially, serotoninergic systems and, as a consequence, enhance adaptogenic functions of organisms;

7. Show positive neuroprotecting (e.g., Alzheimer’s disease) and non-specific analgesic effects;

8. HyFn's do not kill tumor cells, they inhibit cancer pathology development or metastasis;

9. Possess anti-atherosclerotic (anti-atherogenic) properties;

10. Are able to protect against viral infection (e.g., influenza, etc.): (HyFn do not kill viruses and microbes, but do not allow them to incorporate into cells).

Source:  Fullerenes, Nanotubes, and Carbon Nanostructures, 13: 363–376, 2005; Is the C60 Fullerene Molecule Toxic?!

Related See Buckymedicine from ScienceNews 2002

Both nanotechnology researchers Ralph C. Merkle, Ph.D., and the father of nanomedicine Robert A. Freitas, Jr., predicted that fullerene-based therapies would first start appearing on the market by 2009. With hydrated fullerenes we could be on track.

see Nanobiotech Pioneers Predict Nanomedicine Impact within Five Years

On Cancer and Hydratated Fullerenes: ON MEDICINAL AND PREVENTIVE EFFICACY OF SMALL DOZES OF HYDRATED C60 FULLERENES AT THE MODELING CANCER PATHOLOGIES. see here

N.B. don't confuse this research with all the pseudoscience crap, junk science and quackery about "activated' or "revitalized "water that is on the internet that is being sold by scam artists

Comments

[lobo00]

This is the first time I’ve read about carbon Fullerenes used in this way it would be wonderful if the research works out.
I recently saw another article on Alzheimer's about drinking coffee two studies
One from a hospital clinic in Portagul and one in a university clinic located in Berlin, Germany.
Articles can be found at http://www.rayzsite.com/Alzheimer2.php
Bob Harris [email protected]