Quebec City, October 2, 2013—Researchers from Université Laval's Faculty of
Medicine and CHU de Québec have shown that it is possible to treat venous ulcers
unresponsive to conventional treatment with wound dressings made from human skin
grown in vitro. A study published recently in the journal Advances in Skin
and Wound Care demonstrates how this approach was successfully used to treat
venous lower-extremity ulcers in patients who had been chronically suffering
from such wounds.
About 1% of the population suffers from lower-extremity ulcers. These wounds
regularly become inflamed or infected and are very slow to heal, if they do at
all. They are frequently associated with aging, diabetes, and circulatory system
disorders such as varicose veins and oedema. "Obese individuals and those who
work constantly standing up are especially vulnerable. These ulcers can persist
for years. It can be a hellish clinical situation when standard treatments don't
work," noted Dr. François A. Auger, director of both the study and LOEX, the
tissue engineering and regenerative medicine laboratory where it was
conducted.
Standard treatment for ulcers involves methodically cleaning these wounds and
applying compression bandages. Drugs became available around 20 years ago but
they are expensive and their efficacy has been somewhat limited. A graft using
the patient's own skin can be effective but is problematic because it requires a
significant amount of skin to be removed from elsewhere on the body.
This very problem inspired LOEX researchers to use their expertise with in
vitro skin culture to create biomaterial-free biological wound dressing. The
process is complex and requires several steps: removing 1 cm2 of skin from the
patient, isolating the appropriate cells, growing them in vitro, and creating a
skin substitute with both dermis and epidermis. After eight weeks of growth the
self-assembled sheets of skin substitute can be applied over the ulcers, much
like bandages, and replaced weekly as long as necessary. "This totally
biological bandage is much more than a physical barrier," stresses Dr. Auger.
"The cells secrete molecules that speed up healing by helping to set natural
healing processes in motion. It would be hard to imagine a model closer to the
human body's natural physiology."
Tests were successfully carried out on five patients. It took only an average
of seven weeks to cure 14 ulcers that had been affecting patients for at least
six months, and in some cases, several years. "This is a last recourse once all
other treatment options have been exhausted," notes François A. Auger.
Dr. Auger sees another promising application for these biological bandages:
"We have shown that this is effective for patients with leg ulcers. Now, we
intend to carry out a clinical study to demonstrate that the same treatment
works for patients with serious burns, as soon as we get the necessary
approvals."
In addition to Dr. Auger, the study's co-authors are: Olivier Boa, Chanel
Beaudoin Cloutier, Hervé Genest, Raymond Labbé, Bertrand Rodrigue, Jacques
Soucy, Michel Roy, Frédéric Arsenault, Carlos E. Ospina, Nathalie Dubé,
Marie-Hélène Rochon, Danielle Larouche, Véronique J. Moulin, and Lucie
Germain.
Information:
Dr. François A. Auger
Faculty of Medicine
Université
Laval
418 527-4546
[email protected]
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