PRISTINE C60 fullerenes inhibit THE RATE OF TUMOR GROWTH AND METASTASIS

 

Exp Onc Vol. 33, No. 3 :

• Short communications

• http://exp-oncology.com.ua/article/1776/pristine-c60-fullerenes-inhibit-the-rate-of-tumor-growth-and-metastasis

PRISTINE C60 fullereneS inhibit THE RATE OF TUMOR GROWTH AND METASTASIS

Ritter U.¹, Scharff P., Prylutska S.V.², Burlaka A.P.³, Prylutskyy Yu.I.⁴

• ¹Chemical Laboratory, Institute of Physics, Technical University of Ilmenau, Ilmenau 09684, Germany
• ²Kyiv National Shevchenko University, Kyiv, Ukraine
• ³
• ⁴T. Shevchenko Kyiv National University, Kyiv, 01601, Ukraine

Summary. Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis